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[Dongda news 7 April] (correspondent Xu Feng) recently, Lin Chengqi and Luo zhuojuan, the Key Laboratory of "development and disease-related genes" of the school of life science and technology, Southeast University, published the title of "end initiatives multiple phase separation of the super enrichment complex (SEC) in controlling rapid" in the international top journal science advances In this paper, the research achievements on the formation and mechanism of gene transcriptional extension complex are clarified.
Gene transcription is the first step in the transmission of genetic information carried on DNA. Cell fate, individual development and disease development depend on the differential expression of genes. Professor Lin Chengqi's previous research has identified and found that multi subunit, macromolecular protein complex and super transcription extension complex (SEC) can be released from the suspended state through phosphorylated RNA polymerase II and other factors, so as to promote the effective transcription of downstream genes. However, for a long time, people have been puzzled about how the molecules outside the inner membrane system orderly regulate the life process.
The research team of Southeast University has revealed that SEC mediated multivalent phase separation plays a key role in the transcription pause release of RNA polymerase II, and has provided a new understanding of the mechanism of gene rapid and coordinated transcription activation program from a new perspective. In addition, the authors also found that in mixed lineage leukemia (MLL), the transposition and fusion of SEC and MLL genes can greatly promote sec phase separation, thus promoting the rapid transcription of oncogenes and maintaining high expression. This finding will provide a new direction and thinking for the exploration of human disease pathogenesis related to SEC and drug targeted screening program.
The first author of the study: Guo Chenghao, doctoral student, Lin Chengqi research group, College of life science and technology, Southeast University
First communication unit: Southeast University
Article link: https://advances.sciencemag.org/content/6/14/eaay4858
Source: Southeast University
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