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Small: iridium polymer nanomicelles excited by near-infrared light for cancer photodynamic therapy

2020-04-06 3892012

Compared with the traditional tumor therapy, photodynamic therapy has the advantages of high specificity, non-invasive, and no obvious systemic toxic and side effects. However, there is still a lack of ideal photosensitizers in photodynamic therapy, which limits the clinical application of photodynamic therapy to a certain extent. Iridium complexes have been paid more and more attention in the field of photodynamic therapy because of their heavy atom perturbations, which can improve the trilinear population. However, the traditional small molecule iridium photosensitizers have some defects, such as poor water solubility, easy to be removed, low biocompatibility, limited tumor tissue enrichment ability and weak photoluminescence penetration. Therefore, it is of great significance and challenge to develop iridium photosensitizers with near-infrared excitation, high efficiency, low toxicity and high biocompatibility.
The team of Professor Gou Shaohua of Southeast University and Dr. Xu chenjie of City University of Hong Kong designed and synthesized a kind of metal iridium polymer nano micelle with high water solubility, low dark toxicity, tumor targeting and near-infrared light response. The hydrophilic polyethylene glycol is covalently linked with iridium complex to form a amphiphilic polymer with iridium complex in the main chain, and a phase conversion material excited by near-infrared light is introduced to self assemble into nano micelles in aqueous solution. In order to increase the therapeutic effect and targeting of nano micelles, they introduced rapatinib, a drug with HER2 targeting, at the other end of polyethylene glycol. Under the irradiation of near-infrared light (980 nm), the resulting nano micelles convert the near-infrared light into blue light, and stimulate iridium complexes to produce singlet oxygen, and cooperate with lapatinib to kill tumor cells. In vivo study showed that the growth inhibition rate of nano micelles on human ovarian cancer SKOV3 transplanted tumor in nude mice was over 80%, and there was no obvious side effect. This study provides a potential application strategy for iridium complex photosensitizers in clinical safety and effective application. Related papers were published online in small (DOI: 10.1002 / small. 202000363). Dr. Zhao Jian, young teacher of Southeast University, was the first author, and Fang Lei, associate professor, was one of the corresponding authors. Guess you love it.
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